WebNational Center for Biotechnology Information WebFeb 12, 2002 · In breast cancer, p53 mutation is associated with more aggressive disease and worse overall survival. The frequency of mutation in p53 is, however, lower in breast …
Role of p53 in Human Cancers IntechOpen
WebFeb 14, 2024 · The tumor suppressor P53 plays critical role in preventing cancer. P53 is rarely mutated and remains functional in luminal-type breast cancer(1). According to … WebMar 29, 2024 · Breast cancer is the most frequent malignancy among women worldwide, accounting for about 30% of all cases of cancer and 15% of all cancer deaths in females [1, 2].Although great progress has been achieved in early diagnosis, surgery, chemoradiotherapy, endocrine therapy and targeted therapy over the past decades, BC … selenium c# scroll down
Protein expression based multimarker analysis of breast cancer …
WebFeb 28, 2024 · Breast cancer patients with mutated p53 and high expression of PRR11 or SKA2 expression had worse prognoses than the other groups (Fig. 4E). So, it is possible that p53 indirectly regulated the expression of the gene pair by interacting with other transcription factors, however, the identification and mechanisms of related transcription … WebOct 1, 2024 · TP53 is the most frequently mutated gene in cancer, including breast cancer []. TP53 codes for a transcription factor, p53, that initiates transcription of genes involved … WebFeb 27, 2024 · Introduction to p53. The tumor suppressor p53 is a major transcription factor involved in the regulation of several cellular functions. In cancer, p53 attenuates cell proliferation in response to various stimuli, including DNA damage, nutrient deprivation, hypoxia, hyperproliferative signals, thereby preventing tumor formation 1.Thus, it is aptly … selenium c# framework from scratch