Cisplatin prehydration
WebMay 1, 2024 · Carboplatin Injection is supplied as a sterile, pyrogen-free, aqueous solution available in 50 mg/5 mL, 150 mg/15 mL, 450 mg/45 mL or 600 mg/60 mL multiple-dose vials containing 10 mg/mL of Carboplatin for administration by intravenous infusion. Each mL contains 10 mg Carboplatin and Water for Injection, USP.
Cisplatin prehydration
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WebNational Center for Biotechnology Information http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf
WebPreparation of cisplatin infusion: DBL Cisplatin Injection should be added to 1 litre of sodium chloride IV infusion 0.9%. Aluminium containing equipment should not be used … Web75% (same prehydration as 75 mg/m² dose) less than 45 : Delay until creatinine clearance greater than 45 mL/min, then give 50% of CISplatin dose** **may reinstitute full dose CISplatin if renal function stable or improving after 2 more cycles . 3. Ototoxicity: Dose modifications required for CISplatin, Ototoxicity Dose (CISplatin) less than ...
Web(b) Preparation of cisplatin infusion:DBL Cisplatin Injection should be added to 1 litre of sodium chloride IV infusion 0.9%. (c) Treatment:Following prehydration, administer the … WebObjective: To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity. Methods: We randomized 49 women who …
WebRepetitive doses of intravenous (IV) metoclopramide, 2 mg/kg in 75 ml 5% dextrose in water over 15 minutes was given 30 minutes prior to, and at 1 1/2, 4 1/2, and 7 1/2 hours after beginning cisplatin chemotherapy. Only patients with nausea and/or vomiting received subsequent doses of 2 mg/kg metoclopramide IV every 3 hours as needed.
WebCisplatin is excreted via the multidrug and toxin release (MATE) transporter, and the involvement of the MATE transporter in cisplatin-induced kidney injury has been reported. The MATE transporter is also involved in the excretion of ondansetron, but the effects of 5-HT 3 receptor antagonists used clinically for cisplatin-induced renal injury ... cynthia su mdWebWe report a 48-year-old man with laryngeal cancer who received a massive cisplatin toxic overdose without intravenous prehydration through an error in prescription. He received 400 mg/m (2) of cisplatin over a 4-day period. On day 4, he exhibited a broad range of cisplatin toxicities and emergency plasma exchange was started. cynthia summerson bowling green kyWeba Pre and post hydration therapy required for CISplatin See localhospital policy recommendations. Suggested prehydration for CISplatin therapy: • The administration of etoposide in 1000ml 0.9% NaCl over 1 hour as detailed above may be considered as pre-hydration for CISplatin • Administer CISplatin as described above Post hydration: biltwell grips internal throttleWebThe administration of 8 mg/Kg of DDP+NS produced a significantly better survival (P less than 0.05) compared to that observed in mice receiving DDP+DW. The proportion of long-term survivors was 3.5 times higher in the DDP+NS group (39%) compared to … biltwell gringo with gogglesWebPre-hydration Cisplatin dose < 50mg/m2: N/Saline in 1000ml over 1 hour. If another drug is being given in the regimen e.g. etoposide then this would be used as prehydration i.e. etoposide in 1000ml N/Saline. Cisplatin dose 50mg/m2 < 75mg/m2: N/Saline + KCl 20mmol/L in 1000mls over 1hr plus 100mls 10% mannitol (or equivalent) biltwell gringo with bubble shieldWebSep 4, 2013 · Cisplatin was administered with pre- and post-hydration containing 10 mEq of potassium chloride in 500 ml of fluid over a 60-min period. Immediately before the … biltwell gringo with round gogglesWebDec 4, 2014 · As more than 90% of free cisplatin binds to plasma proteins within 4 h, hydration within that time after initiating treatment is a critical factor in reducing toxicity [ 8 ]. In addition, previous reports have demonstrated that cisplatin-induced Mg depletion may occur in some patients [ 9 ]. cynthia summerson dekalb il