Early endosome antigen 1
WebThe endocytic vesicles mature to early endosomes and then the late endosomes by inward budding of the plasma membrane. The late endosomes turn into MVBs by accumulating the intraluminal vesicles ... Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur J Immunol 2003; … WebSep 17, 2024 · The crucial effectors of Rab5 are early endosome antigen-1 (EEA1) [28, 29], rabaptin-5 [30, 31, 37], rabenosyn-5 [32, 38], APPL1/2 [33, 34], and ZFYVE21 (Table 1). EEA1, a key effector of Rab5 with a molecular weight of 162 kD, is a biomarker for early endosomes and has a parallel coiled-coil homodimer structure.
Early endosome antigen 1
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WebNov 29, 2016 · Early endosome antigen-1 and Ras-related protein-11 expressions were upregulated; however, the localized distributions of these pivotal proteins were altered. We hypothesized that these LVLS were held by the internalized and dispersed particles decreasing the amount of cell membrane available to support the completion of cytokinesis. WebEssential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization. Ca2+ is an essential requirement in membrane fusion, acting through binding proteins such as …
WebEarly Endosome Antigen 1 Studies of EEA1 have been instrumental in defining the localization of PI(3)P. Closer examination of the protein reveals it is a large coiled-coil protein (Figure 138.3a) that can bind to the GTP-bound form of Rab5, a GTPase required for endosomal membrane fusion [17]. WebEarly endosomes are a major cytoplasmic sorting compartment from which receptors and ligands may be distributed to various sites within the cell. Early endosome antigen 1 (EEA1) is a 180 kDa hydrophilic peripheral membrane protein present in cytosol and membrane fractions. Immunofluorescence studies show that EEA1 colocalizes to early …
WebEarly endosome antigen 1 (EEA1) is an early endosomal protein that contains an N-terminal zinc finger motif, a cys-rich C-terminal metal-binding finger, and multiple sites for … WebEarly endosomal antigen 1 (EEA1) is a 162 kDa membrane bound protein component specific to the early endosome and is essential for fusion between early endocytic vesicles. Early endosomes are cytoplasmic compartments which fuse with endocytic vesicles for redistribution of extracellular compounds to alternate destinations. Zinc-finger-like ...
WebJan 30, 2012 · Depletion of Rabenosyn-5, but not of other early endosomal proteins such as early endosome antigen 1, resulted in impaired transferrin uptake and lysosomal degradation of transferrin receptors. These studies reveal a critical role for Rabenosyn-5 in determining the fate of transferrin receptors internalized by clathrin-mediated endocytosis …
WebFeb 1, 2004 · Rab5 together with early endosome antigen 1 (EEA1) 118,119,120 — a phosphoinositide-binding protein — regulate fusion between primary endocytic vesicles and sorting endosomes. More … how do you know airpods are chargingWebEarly endosome antigen 1 (EEA1) is a 170 kDa coiled-coil protein belonging to a group of early endosomal Rab5 effector proteins. EEA1 has a putative role in the tethering/docking of endocytic vesicles prior to their fusion with early endosomes. This protein is characterized as containing a zinc finger-like domain and coiled-coil regions. how do you know an apology is sincereWebItem Monkey Early Endosome Antigen 1 ELISA Kit; Company MyBioSource.com; Price Pricing Info Supplier Page View Company Product Page; Catalog Number MBS051694; Quantity 96 Strip Wells; Applications ELISA; Reactivity Monkey; Detection Target Early Endosome Antigen 1 how do you know blackberries are badWebJul 10, 2024 · At this stage, ingested materials can be recycled back to the plasma membrane, sent to the trans-Golgi Network (TGN), or degraded through endosomal acidification. Each compartment in the pathway is marked by characteristic proteins, such as early endosome antigen 1 (EEA1), lysosomal-associated membrane protein 1 … how do you know beer is expiredWebThe gene Early Endosome Antigen 1 (EEA1) encodes for around 1400 amino acid proteins. It is a peripheral membrane protein associated with the cytoplasmic face of early endosomes. EEA1 is a autoantigen associated with subacute cutaneous systemic lupus erythematosus and is a coiled-coil protein localized to early endosomes and cytosol. how do you know boiled eggs are doneWebMay 15, 2015 · Following entry into host cells, OMVs migrate to early endosome antigen 1 (EEA1)-labelled endosomes where they interact with and are detected by nucleotide-binding oligomerization domain ... phone bits for you stratford upon avonWebNov 28, 2024 · c Statins counter Mycobacterium tuberculosis-induced phagosome arrest by inducing the expression of early endosome antigen 1 (EEA1), which might be due to increased Ca 2+ levels in macrophages. how do you know baby has dropped