WebJul 21, 2024 · Given the recently identified role of PABPC1 in mRNA alternative polyadenylation, our findings suggest that PABPC1 recruits hnRNPLL to the 3'-end of RNA and regulates the transition from membrane Ig to secreted Ig through mRNA alternative polyadenylation. WebDec 1, 2024 · Mechanistically, PABPC1 interacted with PLCB1 and PI3K to amplify PLCB1-mediated EMT via PI3K/AKT/GSK3β/Snail signaling. Ectopic PLCB1 induced resistance to treatment with gemcitabine combined with cisplatin, which could be reversed by the AKT inhibitor MK2206. PLCB1 expression was regulated by miR-26b-5p through direct …
Poly(A) binding protein C1 is essential for efficient L1 ...
WebSep 9, 2014 · Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesivrus, the causative agent of Kaposi’s sarcoma and body cavity lymphomas. During infection KSHV produces a highly abundant long non-coding polyadenylated RNA that is retained in the nucleus known as PAN RNA. Long noncoding RNAs (lncRNA) are key … WebMar 22, 2024 · Eukaryotic mRNAs possess a poly(A) tail at their 3'-end, to which poly(A) binding protein C1 (PABPC1) binds and recruits other proteins that regulate translation. Enhanced poly(A)-dependent translation, which is also PABPC1-dependent, promotes cellular and viral proliferation. PABP-interacting prote … moveinmichigan.com real estate
The association of UBAP2L and G3BP1 mediated by small …
WebJun 27, 2024 · Here, we report that PABPC1 protein expression is post-transcriptionally silenced in adult human and mouse hearts through shortening of its mRNA poly (A) tail, … WebJun 27, 2024 · Here, we report that PABPC1 protein expression is post-transcriptionally silenced in adult human and mouse hearts through shortening of its mRNA poly (A) tail, which results in reduced polysome association and translation of Pabpc1 transcripts. The developmental silencing of PABPC1 is cardiomyocyte-specific and reversible. WebMar 28, 2024 · PABPC1 is highly expressed in ESCC and is correlated with a lower survival rate. PABPC1 promotes ESCC cell proliferation and invasion. Mechanistically, PABPC1 … heater fireplace logs