WebApr 23, 2015 · With the aim of developing polyproline type II helix (PPII) secondary-structure mimetics for the modulation of prolin-rich-mediated protein–protein interactions, the … WebJan 1, 2009 · The polyproline type II (PPII) helix is a prevalent conformation in both folded and unfolded proteins, and is known to play important roles in a wide variety of biological processes. Polyproline itself can also form a type I (PPI) helix, which has …
[PDF] Left-handed polyproline-II helix revisited: proteins causing ...
A polyproline helix is a type of protein secondary structure which occurs in proteins comprising repeating proline residues. A left-handed polyproline II helix (PPII, poly-Pro II) is formed when sequential residues all adopt (φ,ψ) backbone dihedral angles of roughly (-75°, 150°) and have trans isomers of their peptide … See more The PPII helix is defined by (φ,ψ) backbone dihedral angles of roughly (-75°, 150°) and trans isomers of the peptide bonds. The rotation angle Ω per residue of any polypeptide helix with trans isomers is given by the equation See more The poly-Pro I helix is much denser than the PPII helix due to the cis isomers of its peptide bonds. It is also rarer than the PPII conformation because the cis isomer is higher in energy … See more Traditionally, PPII has been considered to be relatively rigid and used as a "molecular ruler" in structural biology, e.g., to calibrate FRET efficiency measurements. However, subsequent … See more WebThe polyproline type II helical bundle fold of the 9.6-kDa springtail (Collembola) AFP from Granisotoma rainieri (a primitive arthropod) … rda office raipur
Solvation stabilizes intercarbonyl n→π* interactions and polyproline II …
WebOct 25, 2010 · The conserved FNR-MRM contains about 25% prolines, which suggests a protein–protein interaction mediated by a polyproline motif. It is known that polyproline ligands feature the conformation of a polyproline type II (PPII) helix when bound to the target protein (11, 12). WebJun 26, 2013 · The poly-l-proline type II (PPII) helix in recent years has emerged clearly as a structural class not only of fibrillar proteins (in collagen, PPII is a dominant conformation) … WebNov 6, 2014 · The polyproline helix type II (PPII) is a regular protein secondary structure with remarkable features, but it is not assigned by most popular assignment tools, and … rda office