WebJul 6, 2024 · Additionally, the expression of PTGS2 (the marker of ferroptosis), p53, SAT1, and ALOX15 was increased by the inhibition of HEATR1 (Figure 2D). WebFeb 7, 2024 · Ptgs2 shRNAs were cloned into a retrovirus-based vector carrying Myc cDNA and tandem shRNAs (shAlox8.2865-shPtgs2.562 or shAlox8.2865-shPtgs2.3383), with which Alox8 and Ptgs2 would be ...
PTGS2 prostaglandin-endoperoxide synthase 2 [ (human)]
WebFeb 17, 2024 · Moreover, PGD2, which is the increased lipid metabolite in the CKD kidneys of Alox15−/−mice, inhibited the epithelial–mesenchymal transition (EMT) in proximal tubular … www.ncbi.nlm.nih.gov Lipid mediators are appreciated for their roles in leukocyte traffic required in host … Advances in our understanding of the mechanisms that bring about the … WebDec 2, 2024 · In vivo, ALOX12/15 is not required for glutathione peroxidase 4 (GPX4) depletion-induced ferroptotic damage in the kidney 16 and T cells, 35 whereas ALOX15 is … 博多の森クリニック 発熱外来
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WebJan 24, 2024 · Ptgs2 (COX2) transcript levels increased 4-fold in OA rats compared with the intact animals (Figure 3B), and none of the tested compounds had an influence on it. Authors own results showed no significant changes in the expression of Alox15 in the lumbar spinal cord at day 21 during OA development. We did not elucidate further … WebPTGS2: Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. ... ALOX15: Arachidonate 15-lipoxygenase; Non-heme ... WebApr 8, 2024 · Notably, upregulation of Ptgs2, a marker of ferroptosis 18, was also abrogated in ALOX12-knockout cells (Fig. 2g). These data demonstrate that ALOX12 is crucial for … bc40j-wf カバー