Web26. sep 2014 · The marrow, spleen, and liver macrophages that catabolize heme and recycle iron require the expression of Spi-C, a transcription factor related to PU.1, the major mediator of myeloid differentiation in early-stage hematopoietic progenitor cells. 6 Using transgenic mice engineered to co-express Spic and green fluorescent protein, Dr. Malay … Web23. júl 2024 · Macrophage heterogeneity in bone marrow and HSC niches. Homeostasis of blood production depends on bone marrow niches that regulate the location and function …
Repression of SPI2 transcription by nitric oxide-producing, IFNγ ...
Web7. júl 2014 · Circulating monocytes enter the spleen and upregulate SpiC, leading to macrophage differentiation, reestablishment of the splenic red-pulp macrophage compartment, and restoration of iron homeostasis. These data provide further evidence that local signaling within tissues might be sufficient to promote the acquisition of specialized … Web12. feb 2024 · The first type, termed immature EBI, comprises a small-sized, domed macrophage attached with early-stage erythroid cells and away from sinusoid, whereas the other, known as mature EBI, is composed of a large and flat macrophage that is attached by late-stage erythroblasts and close to sinusoid. salary of genetic counselor
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Web26. aug 2024 · A SFK inhibitor dasatinib inhibited M2 macrophage accumulation in IAV-infected lungs after treatment with anti-PrP mAbs and abolished the anti-PrP mAb-induced protective activity against lethal influenza infection in mice. Web1. jan 2009 · Tissue macrophages comprise a heterogeneous group of cell types differing in location, surface markers and function 1.Red pulp macrophages are a distinct splenic subset involved in removing senescent red blood cells 2.Transcription factors such as PU.1 and C/EBPα play general roles in myelomonocytic development 3, 4, but the transcriptional … Web22. júl 2010 · The SPI1 gene, also known as PU.1, encodes a member of the E26-transformation-specific family of transcription factors and is expressed specifically in … salary of general practitioner