WebMay 13, 2024 · Several target genes of STAT6 have been identified and characterized. The STAT6 signal transduction pathway serves an important role in mediating the biological functions of IL-4 and IL-13 in processes associated with Th2 immune responses. WebApr 15, 2003 · PD-L1 up-regulation depends on TLR4 and STAT1, whereas PD-L2 expression depends on IL-4Rα and STAT6. Consistent with these results, T helper 1/T helper 2 (Th1/Th2) cells also differentially up-regulate PD-L1 …
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WebSTAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c. For Research Use Only. WebStat6 is critical for IL-4-mediated Th2 cell development, but its molecular mechanism remains unclear. Here we constructed Stat6:ER, a Stat6-estrogen receptor fusion protein … kenwood ecrystal split air conditioner
STAT6 deficiency ameliorates severity of oxazolone colitis by ...
Web摘要： 研究背景:变应性鼻炎(AR,allergic rhinitis)在日常生活中愈发多见,是一种常见的过敏性鼻炎,其多在外部条件与内在基因影响下,由过敏机体直接亦或间接接触暴露于特定过敏原,而后在鼻黏膜发病的变态反应性疾病.目前学界了解到,其主要经IgE介导且以炎性介质和或多种免疫细胞以及细胞因子相互 ... WebIL-4 Administration and Th2 Polarization Improve Insulin Action. The repression of PPARα-regulated program of catabolic metabolism Fig. 1. IL-4 and STAT6 regulate liver nutrient metabolism. (A) IL-4 enhances phosphorylation of STAT6 in … WebFeb 17, 2024 · STAT6 is a member of the signal transduction activator family. The cytokines interleukin (IL)-4 and IL-13 activate STAT6 phosphorylation and promote Th2 cell differentiation [ 15 ]. kenwood electronic oil heater