WebSelect your Portal or Identity Provider. Terms of use Privacy policy Help documentation. English WebJs004 has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. ... tab-004, tab004, tab 004, js-004, js 004, anti-btla monoclonal antibody tab004, anti-b- and t-lymphocyte attenuator monoclonal antibody tab004, icatolimab, icatolimab NCIT ID : C168617 References. 1. National Cancer Institute. NCI Thesaurus Version 18.11d.
Safety, Tolerability and Pharmacokinetics of a Monoclonal
WebTargeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer. (PubMed, Transl Res) - "TAB004 treatment slowed the growth of PDA xenograft compared to IgG control and enhanced survival of mice when combined with 5-FU. Since TAB004 significantly reduced colony forming potential and triggered anoikis in the PDA cells, we … WebFour TAB004 dose levels are planned and include: 0.3, 1, 3 and 10 mg/kg. Part A will be the traditional 3 + 3 design with 3 to 6 subjects per dose level (cohort) and will receive their … penberthy road helston
Safety, Tolerability and Pharmacokinetics of a …
WebSep 11, 2024 · Pancreatic ductal adenocarcinoma (PDA) is a fatal malignancy with poor prognosis and limited treatment options. We have developed a second generation CAR T cell using the variable fragments of a novel monoclonal antibody, TAB004, which specifically binds the tumor-associated-MUC1 (tMUC1). tMUC1 is overexpressed on ~85% of all … WebAn official website of the United States government Menu. Search Search WebTAB004-01 A First-in-Human, Multicenter, Open-Label, Phase 1 Dose-Escalation and Cohort Expansion Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of … medea torrent