WebNov 7, 2024 · Thio-THIP (Fig. 1) is weaker than THIP as a GABAA agonist, but studies have disclosed a unique pharmacological profile of this compound. Whereas Thio-THIP shows … WebIn contrast to THIP, thio-THIP (4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol, 5) was only a weak GABA agonist. Thio-THPO (4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridin-3-ol, 10) was …

Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c

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